We would appreciate your assistance in identifying any errors and to let us know. Jacques Dubochet (born 8 June 1942) is a Swiss scientist, specialist of biophysics . The electron microscope’s resolution has radically improved in the last few years, from mostly showing shapeless blobs to now being able to visualise proteins at atomic resolution. Interview with Chemistry Laureate Jacques Dubochet on 6 December 2017 during the Nobel Week in Stockholm, Sweden.Jacques Dubochet answers the following questions (the links below lead to clip on YouTube):The 2017 Nobel Laureates met at the Grünewald Hall in the Stockholm Concert Hall in Stockholm for the traditional round-table discussion and TV program ‘Nobel Minds’. And the Nobel Prize will put a lot of attention on you. Researchers can now freeze biomolecules mid-movement and visualise processes they have never previously seen, which is decisive for both the basic understanding of life’s chemistry and for the development of pharmaceuticals.Electron microscopes were long believed to only be suitable for imaging dead matter, because the powerful electron beam destroys biological material. This breakthrough proved the technology’s potential.Joachim Frank made the technology generally applicable. Jacques Dubochet - WikiMili, The Free Encyclopedia Biophysicists Jacques Dubochet, Joachim Frank and Richard Henderson have won the Nobel Prize in chemistry for inventing new and better ways to see molecules. So that, when it was possible to vitrify biological material, you could have it in the microscope in the vitrified state and observe it quietly in the electron microscope. Thank you very much indeed and once again congratulations.Did you find any typos in this text? I’ve been, during the twenty years I was at the University of Lausanne, I have devoted a lot of effort to the curriculum – biology and society – and Lausanne at that time was unique in developing this curriculum for all our students. Tel: +41 21 801 0349; fax: +41 21 692 4165; e‐mail: Jacques.Dubochet@unil.ch Fifteen laureates were awarded in 2019, for achievements that have conferred the greatest benefit to humankind. Liquid water evaporates in the electron microscope’s vacuum, which makes the biomolecules collapse. The desired atomic resolution was reached in 2013, and researchers can now routinely produce three-dimensional structures of biomolecules. It was not the kind of additional piece of education, it was a core programme in the study of biology and it still continues. He also speak about another topic close to his heart – the importance of science in society. In the past few years, scientific literature has been filled with images of everything from proteins that cause antibiotic resistance, to the surface of the Zika virus.

The interviewer is Adam Smith, Chief Scientific Officer of Nobel Media. You have been awarded, in part because of your development of vitrification of water and people.AS: So people know about liquid water and they know about ice, but I guess most people don’t know about vitrified water.JD: Yes. Tomorrow morning I give a talk at that course and the idea of this course is to make sure that our students are as good citizens as they are good biologists. In 1981, Alasdair McDowall and Jacques Dubochet, scientists at the European Molecular Biology Laboratory, reported the first successful implementation of cryo-EM. Jacques Dubochet (born 8 June 1942) is a retired Swiss biophysicist. Transcript of the interview He is a former researcher at the European Molecular Biology Laboratory in Heidelberg, Germany, and an honorary professor of biophysics at the University of Lausanne in Switzerland.. Crossref Bo Chen and Joachim Frank , Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule , Microscopy , 65 , 1 , (69) , (2016) .

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